A rapid renal clearance methodology for dextran
نویسندگان
چکیده
منابع مشابه
A porphyrin-PEG polymer with rapid renal clearance.
Tetracarboxylic porphyrins and polyethylene glycol (PEG) diamines were crosslinked in conditions that gave rise to a water-soluble porphyrin polyamide. Using PEG linkers 2 kDa or larger prevented fluorescence self-quenching. This networked porphyrin mesh was retained during dialysis with membranes with a 100 kDa pore size, yet passed through the membrane when centrifugal filtration was applied....
متن کاملRapid renal clearance of immunoreactive canine plasma myoglobin.
Rates and mechanisms of myoglobin removal from plasma were examined in closed-chest dogs, using disappearance patterns of immunoreactivity and radioactivity after i.v. canine myoglobin radiolabeled with 125I. Arterial immunoreactive myoglobin concentration decreased monoexponentially over a 2-decade range, with rate constants of disappearance averaging -0.080 +/- 0.014 min-1 (+/- SD) (correspon...
متن کاملIntravascular persistence and renal clearance of dextran of different molecular sizes in normal children.
During the past two decades dextran has been used extensively as a plasma volume expander in adults, while blood loss in the surgery of children is usually replaced by whole blood transfusion. Today the two main indications for using plasma expanders in children are in burns and other emergency situations when blood is not available. There is, however, increasing awareness of the complications ...
متن کاملRAPID – A Rapid Prototyping Methodology for Embedded Systems
RAPID (rapid advanced processor in development) is a rapid prototyping methodology that systematically reuses known-good hardware, firmware, and software designs to compose application-specific embedded systems. This methodology mitigates many risk factors associated with unknown performance from the design process so there is a higher chance of first pass success. In the development of a high-...
متن کاملRenal clearance of ifosfamide.
Nephrotoxicity is an important clinical side effect of the chemotherapeutic agent ifosfamide. This medication is activated by the hepatic cytochrome P450 system with potentially toxic metabolites produced through both ring hydroxylation and chloroethyl side chain oxidation pathways. Using an isolated perfused rat kidney preparation, we examined the possibility that renal metabolism of ifosfamid...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Kidney International
سال: 1987
ISSN: 0085-2538
DOI: 10.1038/ki.1987.76